Latest article: |
BioMark System for Rapid, Reliable, and Cost Effective Genotyping
 28 Jul 2008: Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation found in the genome of any organism. Although SNP genotypes are a powerful tool for understanding disease disposition and drug metabolism, genotyping of large populations has been impractical because of the running costs and time associated with conventional microwell plate-based systems. This application note demonstrates how the BioMark system is a highly efficient alternative.
Fluidigm Corporation
|
|
|
Recent articles: |
|
BioMark Dynamic Array for Single-Cell Gene Expression Analysis
28 Jul 2008: Historically, single-cell gene expression experiments have been difficult and expensive to perform. This application note demonstrates how Fluidigm has introduced a new single-cell gene expression technique that, when used with the BioMark™ Real-Time PCR System, produces inexpensive, easily reproducible, gene expression results from single-cell samples.
Fluidigm Corporation
|
Efficient Drug Metabolism Studies Using the BioMark System
28 Jul 2008: The BioMark system streamlines drug metabolism studies by allowing accurate copy number and SNP genotyping studies to be performed on a single, easy-to-use system. This experiment demonstrates how the BioMark digital and dynamic arrays are used to determine the copy number of the CYP2D6 gene and the SNP status of the CYP2D6 and CYP2C9 genes.
Fluidigm Corporation
|
Enabling Loss of Heterozygosity Studies Using BioMark Digital Arrays
28 Jul 2008: Loss of heterozygosity (LOH) refers to a change from a heterozygous state in a normal genome to a homozygous state in a paired tumor genome. This application note demonstrates how the 12.765 Digital Array enables a new level of sensitivity and flexibility in detecting LOH, through experiments on abnormal X chromosome copy number or aneuploidy.
Fluidigm Corporation
|
The Study of Copy Number Variations (CNVs) Using the 12.765 Digital Array
28 Jul 2008: Copy number variation (CNV) is a polymorphism studied extensively because of its close association with drug metabolism, cancer, immune diseases, and neurological disorders. Conventional technologies such as comparative genomic hybridization, high density SNP genotyping arrays are limited for CNV analysis. Instead, this application note demonstrates how the 12.765 Digital Array enables a new level of sensitivity and flexibility in detecting copy number variations.
Fluidigm Corporation
|
MicroRNA profiling on a rapidly evolving microfluidic array
 06 May 2008: This application note demonstrates how febit’s Geniom® One Platform provides the ideal tool for scientists to design their own microarrays. Based on microfluidics, the platform allows for the quick and flexible synthesis of oligo arrays using sequence information from public or proprietary sources. This means that the Geniom technology does not only allow high throughput miRNA quantification, but also the verification of newly predicted miRNAs.
febit holding GmbH
|
Silverquant® microarray detection and scanning system
 06 May 2008: Silverquant® is a colorimetric detection method adapted to microarray analysis and an alternative to fluorescent labeling. It is a universal method that can be used for nucleic acids as well as for proteins. This application note describes the chemical and physical principles of the Silverquant colorimetric detection system and compares its technical performance with fluorescent-dye detection methods.
Eppendorf
|
Respiratory: Eosinophil – Inflammation – Adhesion Assay
 08 Feb 2008: Cellix Ltd. has developed a novel Microfluidic Platform consisting of a PC-controlled Nanopump with microfluidic biochips and DucoCell analysis software. This application note demonstrates how eosinophil adhesion to VCAM-1 and ICAM-1 under shear stress can be treated with anti-histamine levocetirizine.
Cellix Ltd
|
Autoimmune: Lymphocyte-Inflammation-Adhesion Assay
08 Feb 2008: Cellix Ltd. has developed a novel Microfluidic Platform consisting of a PC-controlled Nanopump with microfluidic biochips and DucoCell analysis software. This application note demonstrates Non- and PMA-stimulated adhesion of peripheral blood T lymphocytes to VCAM-1 and ICAM-1 under shear stress.
Cellix Ltd
|
Immunology: Immunomodulation-Statins-Sepsis
08 Feb 2008: This application note demonstrates the investigation of T-cell adhesion to ICAM-1 with a mixed sepsis model treated with a range of statins under physiological shear stress using the Cellix Microfluidic Platform SP 1.0.
Cellix Ltd
|
